Plant Transcription Factor Database
Previous version: v3.0
Eutrema salsugineum
M-type_MADS Family
Species TF ID Description
Thhalv10000432mM-type_MADS family protein
Thhalv10000479mM-type_MADS family protein
Thhalv10001151mM-type_MADS family protein
Thhalv10001168mM-type_MADS family protein
Thhalv10002204mM-type_MADS family protein
Thhalv10002346mM-type_MADS family protein
Thhalv10002349mM-type_MADS family protein
Thhalv10002350mM-type_MADS family protein
Thhalv10002352mM-type_MADS family protein
Thhalv10002353mM-type_MADS family protein
Thhalv10002789mM-type_MADS family protein
Thhalv10002808mM-type_MADS family protein
Thhalv10002956mM-type_MADS family protein
Thhalv10002996mM-type_MADS family protein
Thhalv10003315mM-type_MADS family protein
Thhalv10003338mM-type_MADS family protein
Thhalv10003426mM-type_MADS family protein
Thhalv10004409mM-type_MADS family protein
Thhalv10004893mM-type_MADS family protein
Thhalv10005313mM-type_MADS family protein
Thhalv10005435mM-type_MADS family protein
Thhalv10005452mM-type_MADS family protein
Thhalv10007954mM-type_MADS family protein
Thhalv10008961mM-type_MADS family protein
Thhalv10009431mM-type_MADS family protein
Thhalv10009669mM-type_MADS family protein
Thhalv10012000mM-type_MADS family protein
Thhalv10012100mM-type_MADS family protein
Thhalv10015500mM-type_MADS family protein
Thhalv10015516mM-type_MADS family protein
Thhalv10015623mM-type_MADS family protein
Thhalv10015661mM-type_MADS family protein
Thhalv10015908mM-type_MADS family protein
Thhalv10016044mM-type_MADS family protein
Thhalv10017754mM-type_MADS family protein
Thhalv10017787mM-type_MADS family protein
Thhalv10017825mM-type_MADS family protein
Thhalv10019133mM-type_MADS family protein
Thhalv10019449mM-type_MADS family protein
Thhalv10019451mM-type_MADS family protein
Thhalv10019481mM-type_MADS family protein
Thhalv10019516mM-type_MADS family protein
Thhalv10019579mM-type_MADS family protein
Thhalv10019667mM-type_MADS family protein
Thhalv10019681mM-type_MADS family protein
Thhalv10019692mM-type_MADS family protein
Thhalv10019731mM-type_MADS family protein
Thhalv10019751mM-type_MADS family protein
Thhalv10019758mM-type_MADS family protein
Thhalv10019780mM-type_MADS family protein
Thhalv10019810mM-type_MADS family protein
Thhalv10019833mM-type_MADS family protein
Thhalv10019839mM-type_MADS family protein
Thhalv10021183mM-type_MADS family protein
Thhalv10021945mM-type_MADS family protein
Thhalv10022102mM-type_MADS family protein
Thhalv10022126mM-type_MADS family protein
Thhalv10022154mM-type_MADS family protein
Thhalv10022157mM-type_MADS family protein
Thhalv10022229mM-type_MADS family protein
Thhalv10022373mM-type_MADS family protein
Thhalv10022995mM-type_MADS family protein
Thhalv10023175mM-type_MADS family protein
Thhalv10023813mM-type_MADS family protein
Thhalv10023871mM-type_MADS family protein
Thhalv10023873mM-type_MADS family protein
Thhalv10023874mM-type_MADS family protein
Thhalv10023913mM-type_MADS family protein
Thhalv10023980mM-type_MADS family protein
Thhalv10024119mM-type_MADS family protein
Thhalv10024162mM-type_MADS family protein
Thhalv10026703mM-type_MADS family protein
Thhalv10026704mM-type_MADS family protein
Thhalv10027038mM-type_MADS family protein
Thhalv10027162mM-type_MADS family protein
Thhalv10027229mM-type_MADS family protein
Thhalv10027307mM-type_MADS family protein
Thhalv10027470mM-type_MADS family protein
Thhalv10028184mM-type_MADS family protein
Thhalv10028255mM-type_MADS family protein
Thhalv10028282mM-type_MADS family protein
Thhalv10029235mM-type_MADS family protein
Thhalv10029238mM-type_MADS family protein
Thhalv10029256mM-type_MADS family protein
Thhalv10029380mM-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513